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注册送68元体验金电子游戏:CHEN huatao

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注册送68元体验金电子游戏

CHEN Huatao

陈华涛副教授.jpg

Ph.D., Associate Professor, Doctoral Supervisor

Born in Dangshan County, Anhui, China

Contact

Address: College of Veterinary Medicine, Northwest A&F University

No. 22 Xinong Road, Yangling, 712100, Shaanxi, China.

Email: htchen@nwafu.edu.cn; chtchjcht@163.com

1. Education and Work Experience

12.2015 – now, Associate Professor, College of Veterinary Medicine, Northwest A&F University, China

10.2013 – 09.2015, Postdoctoral training, Faculty of Pharmaceutical Sciences, Kyoto University, Japan

10.2010 – 09.2013, Ph.D., Bioresource Sciences, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Japan

09.2007 – 06.2010, Master, Clinical Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, China

09.2003 – 07.2007, Bachelor, Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, China

2. Research and Teaching

Research interests:

Veterinary Obstetrics;

Animal Reproductive Physiology;

Circadian Clock Regulation of Reproduction and Metabolism

Teaching:

Theriogenology, Circadian Clock and Health for bachelor students.

Animal Reproductive Endocrinology for master students.

Special Topics in Animal Biology, Special topic in Reproductive Biology, Advances in Veterinary Biotechnology for doctoral students.

3. Memberships and Academic Services

Committee Member of Chinese Society for Cell Biology-Chinese Society for Biological Rhythms

Committee Member of Chinese Association of Animal Science and Veterinary Medicine-Branch of Veterinary Obstetrics

Senior Member of Chinese Association of Animal Science and Veterinary Medicine

Member of Chinese Society for Cell Biology

Member of American Physiological Society

Member of Chinese Association for Physiological Sciences

Member of Chinese Association of Integrative Medicine

Guest Editor of  Frontiers in Cell and Developmental Biology

Guest Editor of  Frontiers in Genetics

Guest Editor of  Life

4. Honors and Awards

2019/10 The Third Batch of "Young Outstanding Talents Support Plan" of Shaanxi Universities, China

2013/10-2015/09 JSPS Post-doctoral Fellowship

2010/10-2013/09 China Scholarship Council (CSC) Postgraduate Scholarship

5. Publications (Selected Papers)

1. Gao Lei#, Gao Dengke#, Zhang Jing#, Li Cuimei, Wu Meina, Xiao Yaoyao, Yang Luda, Ma Tiantian, Wang Xiaoyu, Zhang Manhui, Yang Dan, Pan Tao, Zhang Haisen, Wang Aihua, Jian Yaping*, Chen Huatao*, Age-related endoplasmic reticulum stress represses testosterone synthesis via attenuation of the circadian clock in Leydig cells,  Theriogenology , 2022, 189: 137-149. (Co-corresponding author)

2. Gao Dengke, Zhao Hongcong, Dong Hao, Li Yating, Zhang Jing, Zhang Haisen, Zhang Yu, Jiang Haizhen, Wang Xiaoyu, Wang Aihua, Jin Yaping, Chen Hutao*, Transcriptional feedback loops in the caprine circadian clock system,  Frontiers in Veterinary Science , 9: 814562, 2022. (Corresponding author)

3. Zhang Jing#, Zhao Lijia#, Li Yating, Dong Hao, Zhang Haisen, Zhang Yu, Ma Tiantian, Yang Luda, Gao Dengke, Wang Xiaoyu, Jiang Haizhen, Li Chao, Wang Aihua, Jin Yaping, Chen Huatao*, Circadian clock regulates granulosa cell autophagy through NR1D1-mediated inhibition of ATG5,  American Journal of Physiology-Cell Physiology , 322(1): C231-C245, 2022. (Corresponding author)

4. Yang Luda#, Ma Tiantian#, Zhao Lijia, Jiang Haizhen, Zhang Jing, Liu Dongyao, Zhang Linlin, Wang Xiaoyu, Pan Tao, Zhang Haisen, Wang Aihua, Chao Hsu-wen, Jin Yaping*, Chen Huatao*, Circadian regulation of apolipoprotein gene expression affects testosterone production in mouse testis.  Theriogenology , 174: 9-19, 2021. (Co-corresponding author)

5. Zhao Lijia, Yang Luda, Zhang Jing, Xiao Yaoyao, Wu Meina, Ma tiantian, Wang Xiaoyu, Zhang Linlin, Jiang Haizhen, Chao Hsu-wen, Wang Aihua, Jian Yaping*, Chen Huatao*,  Bmal1 promotes prostaglandin E2 synthesis by up-regulating  Ptgs2 transcription in response to increasing estradiol levels in day 4 pregnant mice.  American Journal of Physiology-Endocrinology and Metabolism , 320(4): E747-E759, 2021. (Co-corresponding author)

6. Zhao Lijia#, Zhang Jing#, Yang Luda, Zhang Haisen, Zhang Yu, Gao Dengke, Jiang Haizhen, Li Yating, Dong Hao, Ma Tiantian, Wang Xiaoyu, Wu Meina, Wang Aihua, Jin Yaping*, Yuan Yalin*, Chen Huatao*, Glyphosate exposure attenuates testosterone synthesis via NR1D1 inhibition of StAR expression in mouse Leydig cells,  Science of the Total Environment , 785: 147323, 2021. (Co-corresponding author)

7. Xiao Yaoyao#, Zhao Lijia#, Li Weidong#, Wang Xiaoyu, Ma tiantian, Yang Luda, Gao Lei, Li Cuimei, Zhang Manhui, Yang Dan, Zhang Jing, Jiang Haizhen, Zhao Hongcong, Wang Yiqun, Chao Hsu-wen, Wang Aihua, Jin Yaping*, Chen Huatao*, Circadian clock gene   BMAL1 controls testosterone production by regulating steroidogenesis-related gene transcription in goat Leydig cells.  Journal of Cellular Physiology , 236(9): 6706-6725, 2021. (Co-corresponding author)

8. Li Cuimei#, Zhang Linlin#, Ma Tiantian, Gao Lei, Yang Luda, Wu Meina, Pang Zhaoxia, Wang Xiaoyu, Yao Qiyang, Xiao Yaoyao, Zhao Lijia, Liu Wei, Zhao Hongcong, Wang Caixia, Wang Aihua, Jin Yaping*, Chen Huatao*, Bisphenol A attenuates testosterone production in Leydig cells via the inhibition of NR1D1 signaling.  Chemosphere , 263, 128020, 2021.( Co-corresponding author)

9. Zhao Lijia#, Xiao Yaoyao#, Li Cuimei, Zhang Jing, Zhang Yaojia, Wu Meina, Ma Tiantian, Yang Luda, Wang Xiaoyu, Jiang Haizhen, Li Qian, Zhao Hongcong, Wang Yiqun, Wang Aihua, Jin Yaping*, Chen Huatao*, Zearalenone perturbs the circadian clock and inhibits testosterone synthesis in mouse Leydig cells . Journal of Toxicology and Environmental Health, Part A Current Issues , 84(3): 112-124, 2021. (Co-corresponding author)

10. Wang Kun#, Wang Jun#, Zhu Chenglong#, Yang Liandong#, Ren Yandong#, Ruan Jue#, Fan Guangyi#, Hu Jiang#, Xu Wenjie, Bi Xuepeng, Zhu Youan, Song Yue, Chen Huatao, Ma Tiantian, Zhao Ruoping, Jiang Haifeng, Zhang Bin, Feng Chengguang, Yuan Yuan, Gan Xiaoni, Li Yongxin, Zeng Honghui, Liu Qun, Zhang Yaolei, Shao Feng, Hao Shijie, Zhang He, Xu Xun, Liu Xin, Wang Depeng, Zhu Min, Zhang Guojie, Zhao Wenming*, QiuQiang*, He Shunping*, Wang Wen*, African lungfish genome sheds lighton the vertebrate water-to-land transition.   Cell , 184(5): 1362-1376, 2021.

11. Lin Heng#, Huang Yen-Sung#, Fustin Jean-Michel, Doi Masao, Chen Huatao, Lai Hui-Huang, Lin Shu-Hui, Lee Yen-Lurk, King Pei-Chih, Hou Hsien-San, Chen Hao-Wen, Young Pei-Yun, Chao Hsu-wen*, Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver.  Nature Communications , 12(1): 645, 2021.

12. Xiong Yongjie, Yin Qirun, Jin Erhui, Chen Huatao*, He Shaojun*, Selenium attenuates chronic heat stress induced apoptosis via the inhibition of endoplasmic reticulum stress in mouse granulosa cells.   Molecules , 25(3), 557, 2020. (Co-corresponding author)

13. Liu Kun#, Hou Guizhong#, Wang Xiaogang, Chen Huatao, Shi Fuquan, Liu Chang, Zhang Xi, Han Fei, Yang Huan, Zhou Niya, Ao Lin, Liu Jinyi, Cao Jia*, Chen Qing*, Adverse effects of circadian desynchrony on the male reproductive system: an epidemiological and experimental study.  Human Reproduction , 35(7), 1515-1528, 2020.

14. Chen Huatao*, #, GaoLei#, Yang Dan, Xiao Yaoyao, Zhang Manhui, Li Cuimei, Wang Aihua, Jin Yaping*, Coordination between the circadian clock and androgen signaling is required to sustain rhythmic expression of   Elovl3 in mouse liver.   Journal of Biological Chemistry , 294(17): 7046-7056, 2019. (Co-first author; Co-corresponding author)

15. Gao Lei#, Chen Huatao*, #, Li Cuimei, Xiao Yaoyao, Yang Dan, Zhang Manhui, Zhou Dong, Liu Wei, Wang Aihua, Jin Yaping*, ER stress activation impairs the expression of circadian clock and clock-controlled genes in NIH3T3 cells via an ATF4-dependent mechanism.  Cellular Signalling , 57: 89-101, 2019. (Co-first author; Co-corresponding author)

16. Yang Diqi, Jiang Tingting, Liu Jianguo, Zhang Beibei, Lin Pengfei, Chen Huatao, Zhou Dong, Tang Keqiong, Wang Aihua, Jin Yaping*, CREB3 regulatory factor – mTOR – autophagy regulates goat endometrial function during early pregnancy.   Biology of Reproduction , 98(5): 713-721, 2018.

17. Chao Hsu-wen, Doi Masao, Fustin Jean-Michel, Chen Huatao, Murase Kimihiko, Maeda Yuki, Hayashi Hida, Tanaka Rina, Sugawa Maho, Mizuguchi Naoki, Yamaguchi Yoshiaki, Yasunaga Jun-ichirou, Matsuoka Masao, Sakai Mashito, Matsumoto Michihiro, Hamada Shinshichi, Okamura Hitoshi*, Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway.  Nature Communications , 8(1): 2238, 2017.

18. Xiong Yongjie, Chen Huatao, Lin Pengfei, Wang Aihua, Wang Lei, Jin Yaping*, ATF6 knockdown decreases apoptosis, arrests the S phase of the cell cycle, and increases steroid hormone production in mouse granulosa cells.  American Journal of Physiology-Cell Physiology , 312(3): C341-C353, 2017.

19. Chen Huatao#, *, Gao Lei#, Xiong Yongjie, Yang Dan, Li Cuimei, Wang Aihua, Jin Yaping*, Circadian clock and steroidogenic-related gene expression profiles in mouse Leydig cells following dexamethasone stimulation.  Biochemical and Biophysical Research Communications , 483(1): 294-300, 2017. (Co-first author; Co-corresponding author)

20. Zhu Hongmei#, Hu Linyong#, Liu Jun, Chen Huatao, Cui Chenchen, Song Yujie, Jin Yaping*, Zhang Yong*, Generation of β-Lactoglobulin-Modified Transgenic goats by Homologous recombination.  FEBS Journal , 283(24): 4600-4613, 2016.

21. Zhao Lijia, Isayama Keishiro, Chen Huatao, Yamauchi Nobuhiko, Shigeyoshi Yasufumi, Hashimoto Seiichi, Hattori Masa-aki*, The nuclear receptor REV-ERBα represses the transcription of growth/differentiation factor 10 and 15 genes in rat endometrium stromal cells.   Physiological Reports , 4(2): e12663, 2016.

22. Chen Huatao, Isayama Keishiro, Kumazawa Makoto, Zhao Lijia, Nobuhiko Yamauchi, Yasufumi Shigeyoshi, Seiichi Hashimoto, Masa-aki Hattori*, Integration of the nuclear receptor REV-ERBα linked to circadian oscillators in the expression of  Alas1 ,   Ppargc1a , and  Il6 genes in rat granulosa cells.  Chronobiology International , 32(6): 739-749, 2015.

23. Tasaki Hirotaka#, Zhao Lijia#, Isayama Keishiro, Chen Huatao, Yamauchi Nobuhiko, Shigeyoshi Yasufumi, Hashimoto Seiichi, Hattori Masa-aki*, Inhibitory role of REB-ERBα in the expression of bone morphogenetic protein gene family in rat uterus endometrium stromal cells.   American Journal of Physiology-Cell Physiology , 308(7): C528-C538, 2015.

24. Isayama Keishiro, Zhao Lijia, Chen Huatao, Yamauchi Nobuhiko, Shigeyoshi Yasufumi, Hashimoto Seiichi, Hattori Masa-aki*, Removal of REV-ERBα inhibition contributes to prostaglandin G/H synthase 2 expression in rat endometrial stromal cells.  American Journal of Physiology-Endocrinology and Metabolism , 308(8): E650-E661, 2015.

25. Isayama Keishiro, Chen Huatao, Yamauchi Nobuhiko, Hattori Masa-aki*, REV-ERBα Inhibits the PTGS2 Expression in Bovine Uterus Endometrium Stromal and Epithelial Cells Exposed to Ovarian Steroids.   Journal of Reproduction and Development , 60(5): 362-370, 2014.

26. Chen Huatao, Zhao Lijia, Chu Guiyan, Kito Gakushi, Yamauchi Nobuhiko, Shigeyoshi Yasufumi, Hashimoto Seiichi, Hattori Masa-aki*, FSH induces the development of circadian clockwork in rat granulosa cells via a gap junction protein Cx43-dependent pathway.   American Journal of Physiology-Endocrinology and Metabolism , 304(6): E566-E575, 2013.

27. Chen Huatao, Zhao Lijia, Kumazawa Makoto, Yamauchi Nobuhiko, Shigeyoshi Yasufumi, Hashimoto Seiichi, Hattori Masa-aki*, Down-regulation of core clock gene   Bmal1 attenuates expression of progesterone and prostaglandin biosynthesis-related genes in rat luteinizing granulosa cells.   American Journal of Physiology-Cell Physiology , 304(12): C1131-C1140, 2013.

28. Tasaki Hirotaka#, Zhao Lijia#, Isayama Keishiro, Chen Huatao, Yamauchi Nobuhiko, Shigeyoshi Yasufumi, Hattori Masa-aki*, Profiling of circadian genes expressed in the uterus endometrial stromal cells of pregnant rats as revealed by DNA microarray coupled with RNA interference.  Frontiers in Endocrinology , 4: 82, 2013.

29. Chen Huatao, Chu Guiyan, Zhao Lijia, Yamauchi Nobuhiko, Shigeyoshi Yasufumi, Hashimoto Seiichi, Hattori Masa-aki*, Rev-erbα regulates circadian rhythms and   StAR expression in rat granulosa cells as identified by the agonist GSK4112.   Biochemical and Biophysical Research Communications , 420(2): 374-379, 2012.

30. Chu Guiyan, Misawa Izumi, Chen Huatao, Yamauchi Nobuhiko, Shigeyoshi Yasufumi, Hashimoto Seiichi, Hattori Masa-aki*, Contribution of FSH and triiodothyronine to the development of circadian clocks during granulosa cell maturation.  American Journal of Physiology-Endocrinology and Metabolism , 302(6): E645-E653, 2012.

6. Projects and Funding

[1] Molecular mechanisms of hepatic circadian clock control of hepatic triglyceride content via USP2-45/PPARα signaling pathway. General Project, No. 31771301, National Natural Science Foundation of China (NSFC), 600,000 RMB Yuan, 2018 - 2021, grant holder.

[2] Study on the molecular mechanism of BMAL1 mediated goat Leydig cells circadian clock on regulating testosterone synthesis. General Project, No. 31602125, National Natural Science Foundation of China (NSFC), 210,000 RMB Yuan, 2017 - 2019, grant holder.


注册送68元体验金电子游戏手机 v5.2.8 - IOS/安卓版手机APP下载
注册送68元体验金电子游戏手机 v5.2.8 - IOS/安卓版手机APP下载